Quantitative Characterization of Changes in Dynamical Behavior for Single-Particle Tracking Studies

by: D Montiel, H Cang, H Yang

J. Phys. Chem. B, Vol. 110, No. 40. (12 October 2006), pp. 19763-19770.

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DOI, American Chem. Soc. Publications

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Abstract

Abstract: Single-particle tracking experiments have been used widely to study the heterogeneity of a sample. Segments with dissimilar diffusive behaviors are associated with different intermediate states, usually by visual inspection of the tracking trace. A likelihood-based, systematic approach is presented to remove this incertitude. Maximum likelihood estimators are derived for the determination of diffusion coefficients. A likelihood ratio test is applied to the localization of the changes in them. Simulations suggest that the proposed procedure is statistically robust and is able to quantitatively recover time-dependent changes in diffusion coefficients even in the presence of large measurement noise.

@article{citeulike:1420518, abstract = {Abstract: Single-particle tracking experiments have been used widely to study the heterogeneity of a sample. Segments with dissimilar diffusive behaviors are associated with different intermediate states, usually by visual inspection of the tracking trace. A likelihood-based, systematic approach is presented to remove this incertitude. Maximum likelihood estimators are derived for the determination of diffusion coefficients. A likelihood ratio test is applied to the localization of the changes in them. Simulations suggest that the proposed procedure is statistically robust and is able to quantitatively recover time-dependent changes in diffusion coefficients even in the presence of large measurement noise.}, address = {Department of Chemistry, University of California at Berkeley, and Physical Biosciences Division, Lawrence Berkeley National Laboratories, Berkeley, California 94720}, author = {Montiel, D. and Cang, H. and Yang, H. }, citeulike-article-id = {1420518}, doi = {10.1021/jp062024j}, journal = {J. Phys. Chem. B}, keywords = {diffusion, theory}, month = {October}, number = {40}, pages = {19763--19770}, posted-at = {2007-06-28 22:34:20}, priority = {2}, title = {Quantitative Characterization of Changes in Dynamical Behavior for Single-Particle Tracking Studies}, url = {http://dx.doi.org/10.1021/jp062024j}, volume = {110}, year = {2006} }

RIS record

TY - JOUR ID - citeulike:1420518 L3 - citeulike-article-id:1420518 TI - Quantitative Characterization of Changes in Dynamical Behavior for Single-Particle Tracking Studies JF - J. Phys. Chem. B VL - 110 IS - 40 SP - 19763 EP - 19770 AD - Department of Chemistry, University of California at Berkeley, and Physical Biosciences Division, Lawrence Berkeley National Laboratories, Berkeley, California 94720 N2 - Abstract: Single-particle tracking experiments have been used widely to study the heterogeneity of a sample. Segments with dissimilar diffusive behaviors are associated with different intermediate states, usually by visual inspection of the tracking trace. A likelihood-based, systematic approach is presented to remove this incertitude. Maximum likelihood estimators are derived for the determination of diffusion coefficients. A likelihood ratio test is applied to the localization of the changes in them. Simulations suggest that the proposed procedure is statistically robust and is able to quantitatively recover time-dependent changes in diffusion coefficients even in the presence of large measurement noise. KW - diffusion KW - theory AU - Montiel, D AU - Cang, H AU - Yang, H PY - 2006/10/12/ UR - http://dx.doi.org/10.1021/jp062024j ER -

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