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The equilibrium of phosphatidylcholine-cholesterol in monolayers at the air/water interface

by: Izabela Brzozowska, Zbigniew A Figaszewski
Colloids and Surfaces B: Biointerfaces, Vol. 23, No. 1. (January 2002), pp. 51-58.


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Monolayers of either cholesterol (Ch) or phosphatidylcholine (L) or their mixtures were investigated at the air/water interface. The surface tension values of pure and mixed monolayers were used to calculate the [pi]-A isotherms. The theory of equilibrium between components of monolayers at the air/water interface has been developed in order to obtain the stability constant of the Ch-L complex. We considered the equilibrium between L, Ch and the L-Ch complex on the basis of derived equations. We established that egg lecithin and cholesterol formed a 1:1 complex, with stability constant equal to K=2.56×106.


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