Amphetamine Exposure Enhances Accumbal Responses to Reward-Predictive Stimuli in a Pavlovian Conditioned Approach Task

@article{citeulike:3037483, abstract = {Acute and repeated exposure to psychostimulants such as amphetamine enhances the effects of pavlovian conditioned stimuli on conditioned behavior. It is hypothesized that amphetamine facilitates conditioned stimulus (CS) effects by selectively enhancing accumbal neuronal responses to stimuli. To test this hypothesis, rats were trained to discriminate between two pavlovian stimuli. One stimulus (i.e., CS+) was paired with sucrose delivery [i.e., unconditioned stimulus (US)], and the other stimulus (i.e., CS-) was paired with the absence of sucrose. Animals developed a conditioned approach response that occurred during the CS+ but not during the CS-. We tested the effect of different doses of amphetamine (0, 0.25, 0.5, or 1.0 mg/kg) on this conditioned approach behavior as well as on accumbal neuronal responses time locked to the CS+, the CS-, and the US. Acute amphetamine exposure increased conditioned approach behavior during the CS+, but not during the CS-. This change in behavior was associated with a selective increase in the magnitude of accumbal responses during the CS+. Repeated amphetamine administration followed by a drug-free period and reexposure did not affect the conditioned behavior, but increased accumbal responses to the CS+. These findings support the hypothesis that amphetamine exposure enhances behavioral responses to pavlovian conditioned stimuli by amplifying accumbal responses to those stimuli. 10.1523/JNEUROSCI.1071-08.2008}, author = {Wan, Xun and Peoples, Laura L. }, citeulike-article-id = {3037483}, doi = {10.1523/JNEUROSCI.1071-08.2008}, journal = {J. Neurosci.}, month = {July}, number = {30}, pages = {7501--7512}, posted-at = {2008-07-23 19:12:53}, priority = {2}, title = {Amphetamine Exposure Enhances Accumbal Responses to Reward-Predictive Stimuli in a Pavlovian Conditioned Approach Task}, url = {http://dx.doi.org/10.1523/JNEUROSCI.1071-08.2008}, volume = {28}, year = {2008} }

TY - JOUR ID - citeulike:3037483 L3 - citeulike-article-id:3037483 TI - Amphetamine Exposure Enhances Accumbal Responses to Reward-Predictive Stimuli in a Pavlovian Conditioned Approach Task JF - J. Neurosci. VL - 28 IS - 30 SP - 7501 EP - 7512 N2 - Acute and repeated exposure to psychostimulants such as amphetamine enhances the effects of pavlovian conditioned stimuli on conditioned behavior. It is hypothesized that amphetamine facilitates conditioned stimulus (CS) effects by selectively enhancing accumbal neuronal responses to stimuli. To test this hypothesis, rats were trained to discriminate between two pavlovian stimuli. One stimulus (i.e., CS+) was paired with sucrose delivery [i.e., unconditioned stimulus (US)], and the other stimulus (i.e., CS-) was paired with the absence of sucrose. Animals developed a conditioned approach response that occurred during the CS+ but not during the CS-. We tested the effect of different doses of amphetamine (0, 0.25, 0.5, or 1.0 mg/kg) on this conditioned approach behavior as well as on accumbal neuronal responses time locked to the CS+, the CS-, and the US. Acute amphetamine exposure increased conditioned approach behavior during the CS+, but not during the CS-. This change in behavior was associated with a selective increase in the magnitude of accumbal responses during the CS+. Repeated amphetamine administration followed by a drug-free period and reexposure did not affect the conditioned behavior, but increased accumbal responses to the CS+. These findings support the hypothesis that amphetamine exposure enhances behavioral responses to pavlovian conditioned stimuli by amplifying accumbal responses to those stimuli. 10.1523/JNEUROSCI.1071-08.2008 AU - Wan, Xun AU - Peoples, Laura PY - 2008/07/23/ UR - http://dx.doi.org/10.1523/JNEUROSCI.1071-08.2008 ER -