Dopamine transporter inhibition is required for cocaine-induced stereotypy.

by: MR Tilley, HH Gu

Neuroreport, Vol. 19, No. 11. (16 July 2008), pp. 1137-1140.

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Abstract

The primary mechanism by which cocaine induces stereotypy has been difficult to discern because cocaine has three high-affinity targets: the reuptake transporters for dopamine (DAT), norepinephrine, and serotonin. To dissect out the role of DAT in cocaine effects, we generated a knock-in mouse line with a cocaine-insensitive DAT (DAT-CI mice). DAT-CI mice provide a powerful tool that can directly test whether DAT inhibition is important for cocaine-induced stereotypy. We found that acute cocaine failed to produce stereotypy in DAT-CI mice. In fact, 40 mg/kg cocaine suppressed stereotypy in DAT-CI mice but produced profound stereotypy in wild-type mice. These findings suggest that DAT inhibition is necessary for cocaine-induced stereotypy. Furthermore, mechanisms independent of DAT inhibition appear to inhibit stereotypy.

@article{citeulike:2967497, abstract = {The primary mechanism by which cocaine induces stereotypy has been difficult to discern because cocaine has three high-affinity targets: the reuptake transporters for dopamine (DAT), norepinephrine, and serotonin. To dissect out the role of DAT in cocaine effects, we generated a knock-in mouse line with a cocaine-insensitive DAT (DAT-CI mice). DAT-CI mice provide a powerful tool that can directly test whether DAT inhibition is important for cocaine-induced stereotypy. We found that acute cocaine failed to produce stereotypy in DAT-CI mice. In fact, 40 mg/kg cocaine suppressed stereotypy in DAT-CI mice but produced profound stereotypy in wild-type mice. These findings suggest that DAT inhibition is necessary for cocaine-induced stereotypy. Furthermore, mechanisms independent of DAT inhibition appear to inhibit stereotypy.}, address = {Departments of aPharmacology bPsychiatry, Ohio State University College of Medicine, Ohio, USA.}, author = {Tilley, M. R. and Gu, H. H. }, citeulike-article-id = {2967497}, doi = {10.1097/WNR.0b013e3283063183}, issn = {0959-4965}, journal = {Neuroreport}, month = {July}, number = {11}, pages = {1137--1140}, posted-at = {2008-07-06 17:20:30}, priority = {2}, title = {Dopamine transporter inhibition is required for cocaine-induced stereotypy.}, url = {http://dx.doi.org/10.1097/WNR.0b013e3283063183}, volume = {19}, year = {2008} }

RIS record

TY - JOUR ID - citeulike:2967497 L3 - citeulike-article-id:2967497 TI - Dopamine transporter inhibition is required for cocaine-induced stereotypy. JF - Neuroreport VL - 19 IS - 11 SP - 1137 EP - 1140 AD - Departments of aPharmacology bPsychiatry, Ohio State University College of Medicine, Ohio, USA. SN - 0959-4965 N2 - The primary mechanism by which cocaine induces stereotypy has been difficult to discern because cocaine has three high-affinity targets: the reuptake transporters for dopamine (DAT), norepinephrine, and serotonin. To dissect out the role of DAT in cocaine effects, we generated a knock-in mouse line with a cocaine-insensitive DAT (DAT-CI mice). DAT-CI mice provide a powerful tool that can directly test whether DAT inhibition is important for cocaine-induced stereotypy. We found that acute cocaine failed to produce stereotypy in DAT-CI mice. In fact, 40 mg/kg cocaine suppressed stereotypy in DAT-CI mice but produced profound stereotypy in wild-type mice. These findings suggest that DAT inhibition is necessary for cocaine-induced stereotypy. Furthermore, mechanisms independent of DAT inhibition appear to inhibit stereotypy. AU - Tilley, MR AU - Gu, HH PY - 2008/07/16/ UR - http://dx.doi.org/10.1097/WNR.0b013e3283063183 ER -

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