Nanotechnology in the diagnosis of atherosclerotic disease

@article{citeulike:3179894, abstract = {Background: Atherosclerosis is a chronic, inflammatory disease in which ruptured plaques can lead to serious thrombotic events, including myocardial infarction or stroke. Often these cardiovascular events occur with no previous recognition of symptoms and only moderate stenosis. New diagnostic techniques are needed for earlier diagnosis and staging of atherosclerotic disease, so appropriate treatments, interventional procedures, or lifestyle changes can begin. Recent developments in nanotechnology could advance clinical imaging of molecular biomarkers, particularly for cardiovascular diagnosis. Objective: In this review, selected nanotechnologies under development for early detection of atherosclerotic disease and identification of vulnerable plaques are presented. Method: The scope of this review encompasses molecular imaging of atherosclerosis using nanoparticle contrast agents. Nanoparticle approaches are grouped by their corresponding diagnostic imaging modality. Results/conclusion: Diagnostic imaging techniques employing nanoparticle contrast agents targeted to molecular signatures of atherosclerotic disease offer hope for improved non-invasive detection.}, author = {Erpelding, Todd N. and Caruthers, Shelton D. and Wickline, Samuel A. and Lanza, Gregory M. }, citeulike-article-id = {3179894}, doi = {http://dx.doi.org/10.1517/17530059.2.6.635}, issn = {1753-0059}, journal = {Expert Opinion on Medical Diagnostics}, keywords = {atherosclerotic, citedby, nanotechnology}, month = {June}, pages = {635--649}, posted-at = {2008-09-01 21:14:55}, priority = {2}, publisher = {Informa Healthcare}, title = {Nanotechnology in the diagnosis of atherosclerotic disease}, url = {http://dx.doi.org/10.1517/17530059.2.6.635}, year = {2008} }

TY - JOUR ID - citeulike:3179894 L3 - citeulike-article-id:3179894 N2 - Background: Atherosclerosis is a chronic, inflammatory disease in which ruptured plaques can lead to serious thrombotic events, including myocardial infarction or stroke. Often these cardiovascular events occur with no previous recognition of symptoms and only moderate stenosis. New diagnostic techniques are needed for earlier diagnosis and staging of atherosclerotic disease, so appropriate treatments, interventional procedures, or lifestyle changes can begin. Recent developments in nanotechnology could advance clinical imaging of molecular biomarkers, particularly for cardiovascular diagnosis. Objective: In this review, selected nanotechnologies under development for early detection of atherosclerotic disease and identification of vulnerable plaques are presented. Method: The scope of this review encompasses molecular imaging of atherosclerosis using nanoparticle contrast agents. Nanoparticle approaches are grouped by their corresponding diagnostic imaging modality. Results/conclusion: Diagnostic imaging techniques employing nanoparticle contrast agents targeted to molecular signatures of atherosclerotic disease offer hope for improved non-invasive detection. JF - Expert Opinion on Medical Diagnostics SN - 1753-0059 EP - 649 TI - Nanotechnology in the diagnosis of atherosclerotic disease PB - Informa Healthcare SP - 635 KW - atherosclerotic KW - citedby KW - nanotechnology AU - Erpelding, Todd AU - Caruthers, Shelton AU - Wickline, Samuel AU - Lanza, Gregory PY - 2008/06// UR - http://dx.doi.org/10.1517/17530059.2.6.635 ER -