The positron emission mammography/tomography breast imaging and biopsy system (PEM/PET): design, construction and phantom-based measurements

@article{citeulike:2630123, abstract = {Tomographic breast imaging techniques can potentially improve detection and diagnosis of cancer in women with radiodense and/or fibrocystic breasts. We have developed a high-resolution positron emission mammography/tomography imaging and biopsy device (called PEM/PET) to detect and guide the biopsy of suspicious breast lesions. PET images are acquired to detect suspicious focal uptake of the radiotracer and guide biopsy of the area. Limited-angle PEM images could then be used to verify the biopsy needle position prior to tissue sampling. The PEM/PET scanner consists of two sets of rotating planar detector heads. Each detector consists of a 4 \&\#215; 3 array of Hamamatsu H8500 flat panel position sensitive photomultipliers (PSPMTs) coupled to a 96 \&\#215; 72 array of 2 \&\#215; 2 \&\#215; 15 mm3 LYSO detector elements (pitch = 2.1 mm). Image reconstruction is performed with a three-dimensional, ordered set expectation maximization (OSEM) algorithm parallelized to run on a multi-processor computer system. The reconstructed field of view (FOV) is 15 \&\#215; 15 \&\#215; 15 cm3. Initial phantom-based testing of the device is focusing upon its PET imaging capabilities. Specifically, spatial resolution and detection sensitivity were assessed. The results from these measurements yielded a spatial resolution at the center of the FOV of 2.01 \&\#177; 0.09 mm (radial), 2.04 \&\#177; 0.08 mm (tangential) and 1.84 \&\#177; 0.07 mm (axial). At a radius of 7 cm from the center of the scanner, the results were 2.11 \&\#177; 0.08 mm (radial), 2.16 \&\#177; 0.07 mm (tangential) and 1.87 \&\#177; 0.08 mm (axial). Maximum system detection sensitivity of the scanner is 488.9 kcps \&\#181;Ci[?]1 ml[?]1 (6.88\%). These promising findings indicate that PEM/PET may be an effective system for the detection and diagnosis of breast cancer. For more information on this article, see medicalphysicsweb.org}, author = {Raylman, Raymond R. and Majewski, Stan and Smith, Mark F. and Proffitt, James and Hammond, William and Srinivasan, Amarnath and Mckisson, John and Popov, Vladimir and Weisenberger, Andrew and Judy, Clifford O. and Kross, Brian and Ramasubramanian, Srikanth and Banta, Larry E. and Kinahan, Paul E. and Champley, Kyle }, citeulike-article-id = {2630123}, doi = {http://dx.doi.org/10.1088/0031-9155/53/3/009}, journal = {Physics in Medicine and Biology}, keywords = {biopsy, breast, design, imaging, pem, pet, phantom, system, tomography}, number = {3}, pages = {637--653}, posted-at = {2008-04-04 17:18:31}, priority = {2}, title = {The positron emission mammography/tomography breast imaging and biopsy system (PEM/PET): design, construction and phantom-based measurements}, url = {http://dx.doi.org/10.1088/0031-9155/53/3/009}, volume = {53}, year = {2008} }

TY - JOUR ID - citeulike:2630123 L3 - citeulike-article-id:2630123 N2 - Tomographic breast imaging techniques can potentially improve detection and diagnosis of cancer in women with radiodense and/or fibrocystic breasts. We have developed a high-resolution positron emission mammography/tomography imaging and biopsy device (called PEM/PET) to detect and guide the biopsy of suspicious breast lesions. PET images are acquired to detect suspicious focal uptake of the radiotracer and guide biopsy of the area. Limited-angle PEM images could then be used to verify the biopsy needle position prior to tissue sampling. The PEM/PET scanner consists of two sets of rotating planar detector heads. Each detector consists of a 4 × 3 array of Hamamatsu H8500 flat panel position sensitive photomultipliers (PSPMTs) coupled to a 96 × 72 array of 2 × 2 × 15 mm3 LYSO detector elements (pitch = 2.1 mm). Image reconstruction is performed with a three-dimensional, ordered set expectation maximization (OSEM) algorithm parallelized to run on a multi-processor computer system. The reconstructed field of view (FOV) is 15 × 15 × 15 cm3. Initial phantom-based testing of the device is focusing upon its PET imaging capabilities. Specifically, spatial resolution and detection sensitivity were assessed. The results from these measurements yielded a spatial resolution at the center of the FOV of 2.01 ± 0.09 mm (radial), 2.04 ± 0.08 mm (tangential) and 1.84 ± 0.07 mm (axial). At a radius of 7 cm from the center of the scanner, the results were 2.11 ± 0.08 mm (radial), 2.16 ± 0.07 mm (tangential) and 1.87 ± 0.08 mm (axial). Maximum system detection sensitivity of the scanner is 488.9 kcps µCi[?]1 ml[?]1 (6.88%). These promising findings indicate that PEM/PET may be an effective system for the detection and diagnosis of breast cancer. For more information on this article, see medicalphysicsweb.org IS - 3 JF - Physics in Medicine and Biology EP - 653 TI - The positron emission mammography/tomography breast imaging and biopsy system (PEM/PET): design, construction and phantom-based measurements VL - 53 SP - 637 KW - biopsy KW - breast KW - design KW - imaging KW - pem KW - pet KW - phantom KW - system KW - tomography AU - Raylman, Raymond AU - Majewski, Stan AU - Smith, Mark AU - Proffitt, James AU - Hammond, William AU - Srinivasan, Amarnath AU - Mckisson, John AU - Popov, Vladimir AU - Weisenberger, Andrew AU - Judy, Clifford AU - Kross, Brian AU - Ramasubramanian, Srikanth AU - Banta, Larry AU - Kinahan, Paul AU - Champley, Kyle PY - 2008/// UR - http://dx.doi.org/10.1088/0031-9155/53/3/009 ER -