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di ramensky library [187 articles]

Articoli aggiunti di recente nella biblioteca di ramensky .
  • Network pharmacology: the next paradigm in drug discovery
    Nat Chem Biol, Vol. 4, No. 11. (November 2008), pp. 682-690.
    by Andrew L Hopkins
    posted to targets selective_binding drug_design by ramensky on 2008-11-19 15:37:40 as ** along with 1 person jerome
  • Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases
    Nat Chem Biol, Vol. 4, No. 11. (November 2008), pp. 691-699.
    by Beth Apsel, Jimmy A Blair, Beatriz Gonzalez, Tamim M Nazif, Morri E Feldman, Brian Aizenstein, Randy Hoffman, Roger L Williams, Kevan M Shokat, Zachary A Knight
    posted to selective_binding drug_design by ramensky on 2008-11-19 15:36:48 as **
  • Kinase-likeness and kinase-privileged fragments: toward virtual polypharmacology.
    Journal of medicinal chemistry, Vol. 51, No. 5. (13 March 2008), pp. 1214-1222.
    by AM Aronov, B McClain, CS Moody, MA Murcko
    posted to selective_binding drug_design by ramensky on 2008-11-19 15:35:42 as **
  • How many modes of action should an antibiotic have?
    Current Opinion in Pharmacology, Vol. 8, No. 5. (October 2008), pp. 564-573.
    by H Brotzoesterhelt, N Brunner
    posted to targets selective_binding drug_design by ramensky on 2008-11-19 15:32:45 as ** along with 1 person zimbo1
  • Kinomics-structural biology and chemogenomics of kinase inhibitors and targets.
    Biochim Biophys Acta, Vol. 1697, No. 1-2. (11 March 2004), pp. 243-257.
    by M Vieth, RE Higgs, DH Robertson, M Shapiro, EA Gragg, H Hemmerle
    posted to selective_binding drug_design by ramensky on 2008-11-19 15:30:57 as ** along with 1 person tjimenez
  • Global mapping of pharmacological space
    Nature Biotechnology, Vol. 24, No. 7. (13 July 2006), pp. 805-815.
    by Gaia V Paolini, Richard HB Shapland, Willem P van Hoorn, Jonathan S Mason, Andrew L Hopkins
    posted to targets drug_design by ramensky on 2008-11-19 15:26:26 as ** along with 8 people and 1 group Yanno BragilMassoud jyuh kuhn bicko caporaso allmensch jerome_ucsf_slb biomedical-nlp
  • Nanobacteria: Facts or Fancies?
    PLoS Pathog, Vol. 3, No. 5. (25 May 2007), e55.
    by Pasquale Urbano, Francesco Urbano
    posted to misc by ramensky on 2008-11-18 12:17:53 as **
  • Drug[mdash]target network
    Nat Biotech, Vol. 25, No. 10. (October 2007), pp. 1119-1126.
    by Muhammed A Yildirim, Kwang-Il Goh, Michael E Cusick, Albert-Laszlo Barabasi, Marc Vidal
    posted to targets drug_similarity drug_design by ramensky on 2008-11-17 23:20:01 as ** along with 12 people and 1 group ptrobajo Yanno jyuh cannin jfr julius grahamc cjeans zwang dejori mingzhi jerome_ucsf_slb libr
  • Detection of 3D atomic similarities and their use in the discrimination of small molecule protein-binding sites
    Bioinformatics, Vol. 24, No. 16. (15 August 2008), pp. i105-111.
    by Rafael Najmanovich, Natalja Kurbatova, Janet Thornton
    posted to drug_design 3d by ramensky on 2008-11-15 21:03:31 as ** along with 5 people apaydin tjimenez neils reyez nickolay
  • Reaching for high-hanging fruit in drug discovery at protein–protein interfaces
    Nature, Vol. 450, No. 7172. (12 December 2007), pp. 1001-1009.
    by James A Wells, Christopher L Mcclendon
    posted to protein-protein drug_design by ramensky on 2008-11-15 20:59:44 as ** along with 6 people cjeans chgjb phoenixzxl higueruelo bicko jyuh
  • Signs of positive selection of somatic mutations in human cancers detected by EST sequence analysis.
    BMC cancer, Vol. 6 (2006)
    by VN Babenko, MK Basu, FA Kondrashov, IB Rogozin, EV Koonin
    posted to evolution cancer adaptation by ramensky on 2008-11-10 14:27:49 as **
  • Protein-ligand docking: Current status and future challenges.
    Proteins (21 July 2006)
    by Sérgio Filipe F Sousa, Pedro Alexandrino A Fernandes, Maria João J Ramos
    posted to drug_design by ramensky on 2008-11-01 18:58:08 as ** along with 9 people and 2 groups BragilMassoud yongzhao peprovy kazemi sergio_fms carlescorbi robert boris_aguilar qaiser_fatmi TSRI_MGL group
  • Combinatorial patterns of somatic gene mutations in cancer.
    The FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 22, No. 8. (August 2008), pp. 2605-2622.
    by CH Yeang, F McCormick, A Levine
    posted to cancer by ramensky on 2008-10-05 17:15:25 as ** along with 2 people srp33 jfr
  • Intragenic Dominant Suppressors of glp-1, a Gene Essential for Cell-Signaling in Caenorhabditis elegans, Support a Role for cdc10/SW16/Ankyrin Motifs in GLP-1 Function
    Genetics, Vol. 135, No. 4. (1 December 1993), pp. 1023-1034.
    by JL Lissemore, PD Currie, CM Turk, EM Maine
    posted to cpds by ramensky on 2008-09-13 14:47:54 as ** along with 1 person and 1 group tharris C. elegans / WormBase
  • Genetic suppression.
    WormBook : the online review of C. elegans biology (2005), pp. 1-13.
    by J Hodgkin
    posted to cpds by ramensky on 2008-09-13 14:32:12 as ** along with 1 person and 1 group tharris C. elegans / WormBase
  • New method for fast and accurate binding-site identification and analysis.
    Chemical biology & drug design, Vol. 69, No. 2. (February 2007), pp. 146-148.
    by T Halgren
    posted to drug_design by ramensky on 2008-09-12 17:41:29 as ** along with 1 person LamBras
  • A detailed comparison of current docking and scoring methods on systems of pharmaceutical relevance.
    Proteins, Vol. 56, No. 2. (1 August 2004), pp. 235-249.
    by E Perola, WP Walters, PS Charifson
    posted to validation drug_design by ramensky on 2008-09-04 15:38:13 as ** along with 4 people and 3 groups BragilMassoud yongzhao marcius schlauchi TSRI_MGL BioinfoCIPF SGU-CIPF
  • On evaluating molecular-docking methods for pose prediction and enrichment factors.
    J Chem Inf Model, Vol. 46, No. 1. (b 2006), pp. 401-415.
    by H Chen, PD Lyne, F Giordanetto, T Lovell, J Li
    posted to validation drug_design by ramensky on 2008-09-04 15:37:27 as ** along with 1 person BragilMassoud
  • Method for comparing the structures of protein ligand-binding sites and application for predicting protein-drug interactions
    Proteins: Structure, Function, and Bioinformatics, Vol. 9999, No. 9999. (2008), NA.
    by Ryoichi Minai, Yo Matsuo, Hiroyuki Onuki, Hiroshi Hirota
    posted to drug_design by ramensky on 2008-09-03 17:49:55 as ** along with 5 people tjimenez massivemayhem jteyra mingzhi higueruelo
  • Side-chain flexibility in protein-ligand binding: the minimal rotation hypothesis.
    Protein Sci, Vol. 14, No. 4. (April 2005), pp. 1104-1114.
    by MI Zavodszky, LA Kuhn
    posted to drug_design by ramensky on 2008-09-03 17:46:24 as ** along with 8 people and 2 groups BragilMassoud dgruiz yongzhao nknii blackbart kazemi rsantana LamBras TCR_Signaling TSRI_MGL
  • Compensatory Mutation Partially Restores Fitness and Delays Reversion of Escape Mutation within the Immunodominant HLA-B*5703-Restricted Gag Epitope in Chronic Human Immunodeficiency Virus Type 1 Infection
    J. Virol., Vol. 81, No. 15. (1 August 2007), pp. 8346-8351.
    by Hayley Crawford, Julia G Prado, Alasdair Leslie, Stephane Hue, Isobella Honeyborne, Sharon Reddy, Mary van der Stok, Zenele Mncube, Christian Brander, Christine Rousseau, James I Mullins, Richard Kaslow, Paul Goepfert, Susan Allen, Eric Hunter, Joseph Mulenga, Photini Kiepiela, Bruce D Walker, Philip J Goulder
    posted to adaptation cpds by ramensky on 2008-08-31 14:50:00 as **
  • In silico whole-genome scanning of cancer-associated nonsynonymous SNPs and molecular characterization of a dynein light chain tumour variant
    Oncogene, Vol. aop, No. current.
    by Abdel Aouacheria, Vincent Navratil, Wenyu Wen, Ming Jiang, Dominique Mouchiroud, Christian Gautier, Manolo Gouy, Mingjie Zhang, Mingjie Zhang
    posted to cancer nssnps by ramensky on 2008-08-31 14:32:24 as ** along with 1 person Ayest
  • Prediction of Cancer Driver Mutations in Protein Kinases
    Cancer Res, Vol. 68, No. 6. (15 March 2008), pp. 1675-1682.
    by Ali Torkamani, Nicholas J Schork
    posted to cancer by ramensky on 2008-08-23 14:10:08 as **
  • Query3d: a new method for high-throughput analysis of functional residues in protein structures.
    BMC bioinformatics, Vol. 6 Suppl 4 (1 December 2005)
    by G Ausiello, A Via, M Helmer-Citterich
    posted to 3d by ramensky on 2008-08-14 18:46:54 as **
  • LigASite--a database of biologically relevant binding sites in proteins with known apo-structures.
    Nucleic acids research, Vol. 36, No. Database issue. (January 2008)
    by BH Dessailly, MF Lensink, CA Orengo, SJ Wodak
    posted to 3d drug_design by ramensky on 2008-08-13 16:10:58 as **
  • Prospects for identifying functional variation across the genome.
    Proceedings of the National Academy of Sciences of the United States of America, Vol. 102 Suppl 1 (3 May 2005), pp. 6614-6621.
    by SJ Macdonald, AD Long
    posted to rsnps by ramensky on 2008-08-03 15:56:41 as ** along with 1 person jbsaltz
  • Data mining in bioinformatics using Weka.
    Bioinformatics, Vol. 20, No. 15. (12 October 2004), pp. 2479-2481.
    by E Frank, M Hall, L Trigg, G Holmes, IH Witten
    posted to misc by ramensky on 2008-08-03 15:45:48 as ** along with 4 people and 4 groups irenas hampti Cortel beapen dbk-lab Atopic_and_Seborrhoeic_Dermatitis Skin_Deep Applied_Bimatics
  • Predicting Functional Regulatory Polymorphisms.
    Bioinformatics (Oxford, England) (18 June 2008)
    by Ali Torkamani, Nicholas J J Schork
    posted to rsnps by ramensky on 2008-08-03 15:32:18 as ** along with 2 people jyuh djkt
  • Bioinformatics approaches and resources for single nucleotide polymorphism functional analysis.
    Brief Bioinform, Vol. 6, No. 1. (March 2005), pp. 44-56.
    by S Mooney
    posted to nssnps by ramensky on 2008-08-03 15:24:47 as ** along with 1 person and 2 groups indigoviolet Bioinformatics EisenLab
  • Natural selection on human microRNA binding sites inferred from SNP data.
    Nat Genet (29 October 2006)
    by Kevin Chen, Nikolaus Rajewsky
    posted to rsnps by ramensky on 2008-08-03 15:16:34 as ** along with 10 people and 3 groups lp2 jfr tardigrade andersbj mtagaya ealloza plofje Garamonfok heliopais bpcusack Bioinformatics microRNA BioinfoCIPF
  • Toxicogenetics: applications and opportunities.
    Toxicological sciences : an official journal of the Society of Toxicology, Vol. 75, No. 1. (September 2003), pp. 1-6.
    by G Orphanides, I Kimber
    posted to drug_design by ramensky on 2008-08-03 14:27:32 as **
  • Allele-specific gene expression differences in humans.
    Hum Mol Genet, Vol. 13 Spec No 2 (1 October 2004)
    by PR Buckland
    posted to rsnps by ramensky on 2008-08-03 14:26:02 as ** along with 2 people qfwills mimulus_99
  • Influence of human genome polymorphism on gene expression.
    Hum Mol Genet, Vol. 15 Spec No 1 (15 April 2006)
    by T Pastinen, B Ge, TJ Hudson
    posted to rsnps by ramensky on 2008-08-03 14:22:30 as ** along with 5 people qfwills vplagnol qmwwallace jo_davies mimulus_99
  • In Silico Detection of Sequence Variations Modifying Transcriptional Regulation
    PLoS Computational Biology, Vol. 4, No. 1. (1 January 2008), e5.
    by Malin C Andersen, Pär G Engström, Stuart Lithwick, David Arenillas, Per Eriksson, Boris Lenhard, Wyeth W Wasserman, Jacob Odeberg
    posted to rsnps by ramensky on 2008-08-03 14:17:27 as ** along with 2 people jyuh renatomilani
  • Genetic susceptibility to age-related macular degeneration: a paradigm for dissecting complex disease traits.
    Human molecular genetics, Vol. 16 Spec No. 2 (15 October 2007)
    by A Swaroop, KE Branham, W Chen, G Abecasis
    posted to association_studies by ramensky on 2008-07-24 15:55:08 as **
  • Multiple elements jointly determine inhibitor selectivity of cyclic nucleotide phosphodiesterases 4 and 7.
    The Journal of biological chemistry, Vol. 280, No. 35. (2 September 2005), pp. 30949-30955.
    by H Wang, Y Liu, Y Chen, H Robinson, H Ke
    posted to drug_design selective_binding by ramensky on 2008-07-16 17:22:42 as **
  • Proportionally more deleterious genetic variation in European than in African populations
    Nature, Vol. 451, No. 7181. (21 February 2008), pp. 994-997.
    by Kirk E Lohmueller, Amit R Indap, Steffen Schmidt, Adam R Boyko, Ryan D Hernandez, Melissa J Hubisz, John J Sninsky, Thomas J White, Shamil R Sunyaev, Rasmus Nielsen, Andrew G Clark, Carlos D Bustamante
    posted to association_studies nssnps by ramensky on 2008-07-04 14:19:18 as ** along with 4 people and 1 group alexeid djkt caseybrown mailund Fasting, food and evolution
  • In silico prediction of the deleterious effect of a mutation: proceed with caution in clinical genetics.
    Clin Chem, Vol. 50, No. 11. (November 2004), pp. 1974-1978.
    by D Tchernitchko, M Goossens, H Wajcman
    posted to nssnps by ramensky on 2008-06-24 00:20:35 as ** along with 1 person chrn
  • Screening for Deleterious Nonsynonymous Single-Nucleotide Polymorphisms in Genes Involved in Steroid Hormone Metabolism and Response
    Cancer Epidemiol Biomarkers Prev, Vol. 14, No. 5. (1 May 2005), pp. 1326-1329.
    by Melissa M Johnson, John Houck, Chu Chen
    posted to nssnps by ramensky on 2008-06-24 00:17:51 as ** along with 1 person Run7
  • Functional characterization of non-synonymous single nucleotide polymorphisms in the gene encoding human multidrug resistance protein 1 (MRP1/ABCC1).
    Pharmacogenet Genomics, Vol. 15, No. 9. (September 2005), pp. 647-657.
    by IJ Létourneau, RG Deeley, SP Cole
    posted to nssnps personalized_medicine by ramensky on 2008-06-23 22:42:29 as ** along with 1 person happy_manatee
  • The structure of common genetic variation in United States populations.
    Am J Hum Genet, Vol. 81, No. 6. (December 2007), pp. 1221-1231.
    by SL Guthery, BA Salisbury, MS Pungliya, JC Stephens, M Bamshad
    posted to association_studies population_genetics by ramensky on 2008-06-19 21:24:13 as ** along with 1 person jyuh
  • Heritability of alternative splicing in the human genome
    Genome Res., Vol. 17, No. 8. (1 August 2007), pp. 1210-1218.
    by Tony Kwan, David Benovoy, Christel Dias, Scott Gurd, David Serre, Harry Zuzan, Tyson A Clark, Anthony Schweitzer, Michelle K Staples, Hui Wang, John E Blume, Thomas J Hudson, Rob Sladek, Jacek Majewski
    posted to alternative_splicing by ramensky on 2008-06-16 21:37:09 as ** along with 8 people and 3 groups dchughes xingxu msomel caseybrown nicholso jo_davies popgen jyuh Bioinformatics G4ID Genetics-of-Gambling
  • Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
    Nature, Vol. 447, No. 7145. (7 June 2007), pp. 661-678.
    posted to association_studies by ramensky on 2008-06-16 21:31:41 as ** along with 26 people and 3 groups Hans45 lkolodziej xingxu raistrick jyuh jfr yas hpiwowar larios vplagnol jandot frohike qmwwallace joepickrell massivemayhem Garamonfok PredictER hms jo_davies psique caseybrown mcgannd raiyar wenhui balicea mfm11 Bioinformatics T_lab parkinson's disease references
  • notes Genome-wide survey of allele-specific splicing in humans
    BMC Genomics, Vol. 9 (02 June 2008), 265.
    by Victoria Nembaware, Bukiwe Lupindo, Katherine Schouest, Charles Spillane, Konrad Scheffler, Cathal Seoighe
    posted to alternative_splicing by ramensky on 2008-06-16 21:28:07 as ** along with 1 person jyuh
  • The Molecular Biology Database Collection: 2008 update
    Nucl. Acids Res. (19 November 2007), gkm1037.
    by Michael Y Galperin
    posted to misc by ramensky on 2008-05-27 23:32:56 as ** along with 7 people and 1 group fgibson frohike moborg dullhunk jmrivort higueruelo AlexanderPico G-quadruplex
  • SNP-SNP interactions in breast cancer susceptibility.
    BMC cancer, Vol. 6 (2006)
    by VU Onay, L Briollais, JA Knight, E Shi, Y Wang, S Wells, H Li, I Rajendram, IL Andrulis, H Ozcelik
    posted to cancer by ramensky on 2008-05-27 21:46:38 as ** along with 1 person and 1 group Zephyrus Breast Cancer Reading Club
  • Can we rationally design promiscuous drugs?
    Curr Opin Struct Biol (24 January 2006)
    by Andrew L L Hopkins, Jonathan S S Mason, John P P Overington
    posted to selective_binding drug_design by ramensky on 2008-05-15 00:34:20 as ** along with 6 people and 1 group BragilMassoud apaydin kuhn bicko yongzhao aheilbut TSRI_MGL
  • How many drug targets are there?
    Nature Reviews Drug Discovery, Vol. 5, No. 12., pp. 993-996.
    by John P Overington, Bissan Al-Lazikani, Andrew L Hopkins
    posted to targets drug_design by ramensky on 2008-05-15 00:33:35 as ** along with 10 people and 1 group BragilMassoud cannin kuhn bicko mingzhi higueruelo srp33 aheilbut gemmalholliday ajaymalik libr
  • A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer
    Nature Genetics, Vol. 37, No. 6. (22 May 2005), pp. 590-592.
    by Philip Stephens, Sarah Edkins, Helen Davies, Chris Greenman, Charles Cox, Chris Hunter, Graham Bignell, Jon Teague, Raffaella Smith, Claire Stevens, Sarah O'Meara, Adrian Parker, Patrick Tarpey, Tim Avis, Andy Barthorpe, Lisa Brackenbury, Gemma Buck, Adam Butler, Jody Clements, Jennifer Cole, Ed Dicks, Ken Edwards, Simon Forbes, Matthew Gorton, Kristian Gray, Kelly Halliday, Rachel Harrison, Katy Hills, Jonathon Hinton, David Jones, Vivienne Kosmidou, Ross Laman, Richard Lugg, Andrew Menzies, Janet Perry, Robert Petty, Keiran Raine, Rebecca Shepherd, Alexandra Small, Helen Solomon, Yvonne Stephens, Calli Tofts, Jennifer Varian, Anthony Webb, Sofie West, Sara Widaa, Andrew Yates, Francis Brasseur, Colin S Cooper, Adrienne M Flanagan, Anthony Green, Maggie Knowles, Suet Y Leung, Leendert HJ Looijenga, Bruce Malkowicz, Marco A Pierotti, Bin Teh, Siu T Yuen, Andrew G Nicholson, Sunil Lakhani, Douglas F Easton, Barbara L Weber, Michael R Stratton, Andrew A Futreal, Richard Wooster
    posted to cancer by ramensky on 2008-04-29 20:34:07 as ** along with 2 people cerami frohike
  • Somatic mutations of the protein kinase gene family in human lung cancer.
    Cancer research, Vol. 65, No. 17. (1 September 2005), pp. 7591-7595.
    by H Davies, C Hunter, R Smith, P Stephens, C Greenman, G Bignell, J Teague, A Butler, S Edkins, C Stevens, A Parker, S O'Meara, T Avis, S Barthorpe, L Brackenbury, G Buck, J Clements, J Cole, E Dicks, K Edwards, S Forbes, M Gorton, K Gray, K Halliday, R Harrison, K Hills, J Hinton, D Jones, V Kosmidou, R Laman, R Lugg, A Menzies, J Perry, R Petty, K Raine, R Shepherd, A Small, H Solomon, Y Stephens, C Tofts, J Varian, A Webb, S West, S Widaa, A Yates, F Brasseur, CS Cooper, AM Flanagan, A Green, M Knowles, SY Leung, LH Looijenga, B Malkowicz, MA Pierotti, BT Teh, ST Yuen, SR Lakhani, DF Easton, BL Weber, P Goldstraw, AG Nicholson, R Wooster, MR Stratton, PA Futreal
    posted to cancer by ramensky on 2008-04-29 20:30:53 as ** along with 1 person frohike
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