Facilitation of saccadic eye movements by postsaccadic electrical stimulation in the primate caudate.

@article{citeulike:997091, abstract = {Sensorimotor experience followed by positive feedback leads to motor learning. Although the striatum, an input channel of the basal ganglia, has been implicated to play a key role in motor learning, little is known about how reward information modulates the neuronal processes in the striatum that causes behavioral changes. Here, we report that direct manipulation of the neuronal signal in the primate caudate yields behavioral changes comparable with those induced by natural reward. Electrical stimulation in the oculomotor region of the caudate immediately after saccades to a fixed direction led to selective facilitation of saccades in that direction. The facilitation remained even after stimulation was stopped, indicating a plastic change. These effects were observed when stimulation was applied after, not before, saccades. We propose that the caudate plays a causal role in behavioral changes by integrating selective sensorimotor and reward information in a temporally specific manner.}, address = {Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892-4435.}, author = {Nakamura, K. and Hikosaka, O. }, citeulike-article-id = {997091}, doi = {10.1523/JNEUROSCI.3688-06.2006}, issn = {1529-2401}, journal = {J Neurosci}, keywords = {reinforcement, saccade, striatum}, month = {December}, number = {50}, pages = {12885--12895}, posted-at = {2006-12-19 10:06:45}, priority = {3}, title = {Facilitation of saccadic eye movements by postsaccadic electrical stimulation in the primate caudate.}, url = {http://dx.doi.org/10.1523/JNEUROSCI.3688-06.2006}, volume = {26}, year = {2006} }

TY - JOUR ID - citeulike:997091 L3 - citeulike-article-id:997091 TI - Facilitation of saccadic eye movements by postsaccadic electrical stimulation in the primate caudate. JF - J Neurosci VL - 26 IS - 50 SP - 12885 EP - 12895 AD - Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892-4435. SN - 1529-2401 N2 - Sensorimotor experience followed by positive feedback leads to motor learning. Although the striatum, an input channel of the basal ganglia, has been implicated to play a key role in motor learning, little is known about how reward information modulates the neuronal processes in the striatum that causes behavioral changes. Here, we report that direct manipulation of the neuronal signal in the primate caudate yields behavioral changes comparable with those induced by natural reward. Electrical stimulation in the oculomotor region of the caudate immediately after saccades to a fixed direction led to selective facilitation of saccades in that direction. The facilitation remained even after stimulation was stopped, indicating a plastic change. These effects were observed when stimulation was applied after, not before, saccades. We propose that the caudate plays a causal role in behavioral changes by integrating selective sensorimotor and reward information in a temporally specific manner. KW - reinforcement KW - saccade KW - striatum AU - Nakamura, K AU - Hikosaka, O PY - 2006/12/13/ UR - http://dx.doi.org/10.1523/JNEUROSCI.3688-06.2006 ER -