Re-emergence of striatal cholinergic interneurons in movement disorders

@article{citeulike:1733588, abstract = {Twenty years ago, striatal cholinergic neurons were central figures in models of basal ganglia function. But since then, they have receded in importance. Recent studies are likely to lead to their re-emergence in our thinking. Cholinergic interneurons have been implicated as key players in the induction of synaptic plasticity and motor learning, as well as in motor dysfunction. In Parkinson's disease and dystonia, diminished striatal dopaminergic signalling leads to increased release of acetylcholine by interneurons, distorting network function and inducing structural changes that undoubtedly contribute to the symptoms. By contrast, in Huntington's disease and progressive supranuclear palsy, there is a fall in striatal cholinergic markers. This review gives an overview of these recent experimental and clinical studies, placing them within the context of the pathogenesis of movement disorders.}, author = {Pisani, Antonio and Bernardi, Giorgio and Ding, Jun and Surmeier, James D. }, citeulike-article-id = {1733588}, doi = {10.1016/j.tins.2007.07.008}, journal = {Trends in Neurosciences}, keywords = {acetylcholine, parkinson, review, tan}, posted-at = {2007-10-06 12:17:03}, priority = {2}, title = {Re-emergence of striatal cholinergic interneurons in movement disorders}, url = {http://dx.doi.org/10.1016/j.tins.2007.07.008}, volume = {In Press, Corrected Proof} }

TY - JOUR ID - citeulike:1733588 L3 - citeulike-article-id:1733588 TI - Re-emergence of striatal cholinergic interneurons in movement disorders JF - Trends in Neurosciences VL - In Press, Corrected Proof N2 - Twenty years ago, striatal cholinergic neurons were central figures in models of basal ganglia function. But since then, they have receded in importance. Recent studies are likely to lead to their re-emergence in our thinking. Cholinergic interneurons have been implicated as key players in the induction of synaptic plasticity and motor learning, as well as in motor dysfunction. In Parkinson's disease and dystonia, diminished striatal dopaminergic signalling leads to increased release of acetylcholine by interneurons, distorting network function and inducing structural changes that undoubtedly contribute to the symptoms. By contrast, in Huntington's disease and progressive supranuclear palsy, there is a fall in striatal cholinergic markers. This review gives an overview of these recent experimental and clinical studies, placing them within the context of the pathogenesis of movement disorders. KW - acetylcholine KW - parkinson KW - review KW - tan AU - Pisani, Antonio AU - Bernardi, Giorgio AU - Ding, Jun AU - Surmeier, James UR - http://dx.doi.org/10.1016/j.tins.2007.07.008 ER -