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Yeast Polo-like kinase substrates are nailed with the right tools

by: Vincent Archambault, David Glover
Genome Biology, Vol. 9, No. 1. (2008)


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A platform has been built combining chemical genetics and bioinformatics to screen the proteome for physiological substrates of the Polo-like kinase in budding yeast. A novel role for this kinase in regulating the mitotic spindle is revealed.


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