Distinct monoubiquitin signals in receptor endocytosis

@article{citeulike:2802144, abstract = {Numerous cellular proteins are post-translationally modified by the addition of the small modifier protein ubiquitin (Ub). The functional consequences of the type of ubiquitination vary, such that polyubiquitinated proteins are targeted for degradation by the proteasome, whereas monoubiquitination is implicated in other cellular functions, including endocytic trafficking and DNA repair. The monoubiquitination of trafficking cargoes, such as receptors and associated proteins, as well as of endocytic accessory Ub-binding proteins, raises the question of the precise function of monoubiquitin signals in the endocytic route. Recent biochemical and genetic evidence shows that multiple monoubiquitination of epidermal growth factor and platelet-derived growth factor receptors provides trafficking and sorting tags that ensure receptor endocytosis and degradation, whereas monoubiquitination of accessory proteins might play a role in regulating their function as Ub-receptors in the endosome.}, author = {Haglund, Kaisa and Di Fiore, Pier P. and Dikic, Ivan }, citeulike-article-id = {2802144}, doi = {10.1016/j.tibs.2003.09.005}, journal = {Trends in Biochemical Sciences}, keywords = {review, ubiquitin}, month = {November}, number = {11}, pages = {598--604}, posted-at = {2008-05-15 18:07:37}, priority = {2}, title = {Distinct monoubiquitin signals in receptor endocytosis}, url = {http://dx.doi.org/10.1016/j.tibs.2003.09.005}, volume = {28}, year = {2003} }

TY - JOUR ID - citeulike:2802144 L3 - citeulike-article-id:2802144 TI - Distinct monoubiquitin signals in receptor endocytosis JF - Trends in Biochemical Sciences VL - 28 IS - 11 SP - 598 EP - 604 N2 - Numerous cellular proteins are post-translationally modified by the addition of the small modifier protein ubiquitin (Ub). The functional consequences of the type of ubiquitination vary, such that polyubiquitinated proteins are targeted for degradation by the proteasome, whereas monoubiquitination is implicated in other cellular functions, including endocytic trafficking and DNA repair. The monoubiquitination of trafficking cargoes, such as receptors and associated proteins, as well as of endocytic accessory Ub-binding proteins, raises the question of the precise function of monoubiquitin signals in the endocytic route. Recent biochemical and genetic evidence shows that multiple monoubiquitination of epidermal growth factor and platelet-derived growth factor receptors provides trafficking and sorting tags that ensure receptor endocytosis and degradation, whereas monoubiquitination of accessory proteins might play a role in regulating their function as Ub-receptors in the endosome. KW - review KW - ubiquitin AU - Haglund, Kaisa AU - Di Fiore, Pier AU - Dikic, Ivan PY - 2003/11// UR - http://dx.doi.org/10.1016/j.tibs.2003.09.005 ER -