Viral RNA Is Required for the Association of APOBEC3G with Human Immunodeficiency Virus Type 1 Nucleoprotein Complexes

by: Mohammad A Khan, Sandra Kao, Eri Miyagi, Hiroaki Takeuchi, Ritu Goila-Gaur, Sandrine Opi, Clay L Gipson, Tristram G Parslow, Hinh Ly, Klaus Strebel

J. Virol., Vol. 79, No. 9. (1 May 2005), pp. 5870-5874.

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Abstract

APOBEC3G (APO3G) is a host cytidine deaminase that is incorporated into human immunodeficiency virus type 1 (HIV-1) particles. We report here that viral RNA promotes stable association of APO3G with HIV-1 nucleoprotein complexes (NPC). A target sequence located within the 5'-untranslated region of the HIV-1 RNA was identified to be necessary and sufficient for efficient APO3G packaging. Fine mapping revealed a sequence normally involved in viral genomic RNA dimerization and Gag binding to be important for APO3G packaging and association with viral NPC. Our data suggest that packaging of APO3G into HIV-1 NPC is enhanced by viral RNA. 10.1128/JVI.79.9.5870-5874.2005

@article{citeulike:2718511, abstract = {APOBEC3G (APO3G) is a host cytidine deaminase that is incorporated into human immunodeficiency virus type 1 (HIV-1) particles. We report here that viral RNA promotes stable association of APO3G with HIV-1 nucleoprotein complexes (NPC). A target sequence located within the 5'-untranslated region of the HIV-1 RNA was identified to be necessary and sufficient for efficient APO3G packaging. Fine mapping revealed a sequence normally involved in viral genomic RNA dimerization and Gag binding to be important for APO3G packaging and association with viral NPC. Our data suggest that packaging of APO3G into HIV-1 NPC is enhanced by viral RNA. 10.1128/JVI.79.9.5870-5874.2005}, author = {Khan, Mohammad A. and Kao, Sandra and Miyagi, Eri and Takeuchi, Hiroaki and Goila-Gaur, Ritu and Opi, Sandrine and Gipson, Clay L. and Parslow, Tristram G. and Ly, Hinh and Strebel, Klaus }, citeulike-article-id = {2718511}, doi = {10.1128/JVI.79.9.5870-5874.2005}, journal = {J. Virol.}, keywords = {apobec, assembly}, month = {May}, number = {9}, pages = {5870--5874}, posted-at = {2008-04-25 15:00:27}, priority = {2}, title = {Viral RNA Is Required for the Association of APOBEC3G with Human Immunodeficiency Virus Type 1 Nucleoprotein Complexes}, url = {http://dx.doi.org/10.1128/JVI.79.9.5870-5874.2005}, volume = {79}, year = {2005} }

RIS record

TY - JOUR ID - citeulike:2718511 L3 - citeulike-article-id:2718511 TI - Viral RNA Is Required for the Association of APOBEC3G with Human Immunodeficiency Virus Type 1 Nucleoprotein Complexes JF - J. Virol. VL - 79 IS - 9 SP - 5870 EP - 5874 N2 - APOBEC3G (APO3G) is a host cytidine deaminase that is incorporated into human immunodeficiency virus type 1 (HIV-1) particles. We report here that viral RNA promotes stable association of APO3G with HIV-1 nucleoprotein complexes (NPC). A target sequence located within the 5'-untranslated region of the HIV-1 RNA was identified to be necessary and sufficient for efficient APO3G packaging. Fine mapping revealed a sequence normally involved in viral genomic RNA dimerization and Gag binding to be important for APO3G packaging and association with viral NPC. Our data suggest that packaging of APO3G into HIV-1 NPC is enhanced by viral RNA. 10.1128/JVI.79.9.5870-5874.2005 KW - apobec KW - assembly AU - Khan, Mohammad AU - Kao, Sandra AU - Miyagi, Eri AU - Takeuchi, Hiroaki AU - Goila-Gaur, Ritu AU - Opi, Sandrine AU - Gipson, Clay AU - Parslow, Tristram AU - Ly, Hinh AU - Strebel, Klaus PY - 2005/05/01/ UR - http://dx.doi.org/10.1128/JVI.79.9.5870-5874.2005 ER -

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