Phosphate levels and blood pressure in incident hemodialysis patients: a longitudinal study.

@article{citeulike:2946463, abstract = {An elevated serum phosphate level in hemodialysis patients has been associated with mineral deposition in blood vessels. We studied a possible physiologic consequence of hyperphosphatemia by examining the relation between serum phosphate levels and blood pressure in 707 incident hemodialysis patients from 75 clinics who were enrolled in a prospective cohort study. We conducted cross-sectional and longitudinal multiple linear regression analyses, adjusting for demographics, medical history, and laboratory factors. In cross-sectional analyses at baseline, elevated serum phosphate was associated with higher predialysis systolic blood pressure (SBP) and pulse pressure (PP) at the start of dialysis; each 1 mg/dL higher phosphate level was associated with 1.77 mm Hg higher SBP. In multivariable adjusted longitudinal analyses, for each 1 mg/dL higher serum phosphate at baseline, SBP was higher at 3 months, 1.36 mm Hg (P = .005); 6 months, 1.13 mm Hg (P = .035); 12 months, 1.65 mm Hg (P = .008); 18 months, 1.44 mm Hg (P = .031); and 27 months, 2.54 mm Hg (P = .002). PP was higher at 3 months, 0.80 mm Hg (P = .027); 6 months, 0.91 mm Hg (P = .022); 12 months, 1.45 mm Hg (P < .001); 18 months, 1.06 mm Hg (P = .026); and 27 months, 1.37 mm Hg (P = .020). This study suggests that serum phosphate level is strongly and independently associated with blood pressure in hemodialysis patients. The effect of rigorous control of serum phosphate levels on arterial stiffness and blood pressure should be studied in clinical trials.}, address = {Johns Hopkins/Sinai Hospital Program in Internal Medicine, Baltimore, MD, USA.}, author = {Huang, C. X. and Plantinga, L. C. and Fink, N. E. and Melamed, M. L. and Coresh, J. and Powe, N. R. }, citeulike-article-id = {2946463}, doi = {10.1053/j.ackd.2008.04.012}, issn = {1548-5609}, journal = {Advances in chronic kidney disease}, keywords = {bp, hd, longitudinal, p}, month = {July}, number = {3}, pages = {321--331}, posted-at = {2008-07-01 03:40:20}, priority = {2}, title = {Phosphate levels and blood pressure in incident hemodialysis patients: a longitudinal study.}, url = {http://dx.doi.org/10.1053/j.ackd.2008.04.012}, volume = {15}, year = {2008} }

TY - JOUR ID - citeulike:2946463 L3 - citeulike-article-id:2946463 TI - Phosphate levels and blood pressure in incident hemodialysis patients: a longitudinal study. JF - Advances in chronic kidney disease VL - 15 IS - 3 SP - 321 EP - 331 AD - Johns Hopkins/Sinai Hospital Program in Internal Medicine, Baltimore, MD, USA. SN - 1548-5609 N2 - An elevated serum phosphate level in hemodialysis patients has been associated with mineral deposition in blood vessels. We studied a possible physiologic consequence of hyperphosphatemia by examining the relation between serum phosphate levels and blood pressure in 707 incident hemodialysis patients from 75 clinics who were enrolled in a prospective cohort study. We conducted cross-sectional and longitudinal multiple linear regression analyses, adjusting for demographics, medical history, and laboratory factors. In cross-sectional analyses at baseline, elevated serum phosphate was associated with higher predialysis systolic blood pressure (SBP) and pulse pressure (PP) at the start of dialysis; each 1 mg/dL higher phosphate level was associated with 1.77 mm Hg higher SBP. In multivariable adjusted longitudinal analyses, for each 1 mg/dL higher serum phosphate at baseline, SBP was higher at 3 months, 1.36 mm Hg (P = .005); 6 months, 1.13 mm Hg (P = .035); 12 months, 1.65 mm Hg (P = .008); 18 months, 1.44 mm Hg (P = .031); and 27 months, 2.54 mm Hg (P = .002). PP was higher at 3 months, 0.80 mm Hg (P = .027); 6 months, 0.91 mm Hg (P = .022); 12 months, 1.45 mm Hg (P < .001); 18 months, 1.06 mm Hg (P = .026); and 27 months, 1.37 mm Hg (P = .020). This study suggests that serum phosphate level is strongly and independently associated with blood pressure in hemodialysis patients. The effect of rigorous control of serum phosphate levels on arterial stiffness and blood pressure should be studied in clinical trials. KW - bp KW - hd KW - longitudinal KW - p AU - Huang, CX AU - Plantinga, LC AU - Fink, NE AU - Melamed, ML AU - Coresh, J AU - Powe, NR PY - 2008/07// UR - http://dx.doi.org/10.1053/j.ackd.2008.04.012 ER -