An Empirical Investigation of Exposure Measurement Bias and Its Components in Case-Control Studies

by: Roger J Marshall

Journal of Clinical Epidemiology, Vol. 52, No. 6. (June 1999), pp. 547-550.

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Abstract

This study investigated bias due to misclassification of exposure in case control studies. Using a metaanalysis of data from a number of case control studies, in which a possibly misclassified exposure was validated against a more reliable one, estimates of misclassification indices and bias were obtained. The estimates were used to investigate whether misclassification indices, in particular, sensitivity and specificity and so-called quality indices, are typically nondifferential with respect to cases and controls. It is concluded that quality indices do not show any tendency to be either lower or higher in cases than controls. On the other hand, sensitivity tends to be higher in cases than controls and specificity lower. Estimates of misclassification bias may be either positive or negative and are consistent with random variation; there is little to suggest that bias is present in the studies analyzed.

@article{citeulike:2808828, abstract = {This study investigated bias due to misclassification of exposure in case control studies. Using a metaanalysis of data from a number of case control studies, in which a possibly misclassified exposure was validated against a more reliable one, estimates of misclassification indices and bias were obtained. The estimates were used to investigate whether misclassification indices, in particular, sensitivity and specificity and so-called quality indices, are typically nondifferential with respect to cases and controls. It is concluded that quality indices do not show any tendency to be either lower or higher in cases than controls. On the other hand, sensitivity tends to be higher in cases than controls and specificity lower. Estimates of misclassification bias may be either positive or negative and are consistent with random variation; there is little to suggest that bias is present in the studies analyzed.}, author = {Marshall, Roger J. }, citeulike-article-id = {2808828}, doi = {10.1016/S0895-4356(99)00028-1}, journal = {Journal of Clinical Epidemiology}, month = {June}, number = {6}, pages = {547--550}, posted-at = {2008-05-18 12:06:59}, priority = {2}, title = {An Empirical Investigation of Exposure Measurement Bias and Its Components in Case-Control Studies}, url = {http://dx.doi.org/10.1016/S0895-4356(99)00028-1}, volume = {52}, year = {1999} }

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TY - JOUR ID - citeulike:2808828 L3 - citeulike-article-id:2808828 TI - An Empirical Investigation of Exposure Measurement Bias and Its Components in Case-Control Studies JF - Journal of Clinical Epidemiology VL - 52 IS - 6 SP - 547 EP - 550 N2 - This study investigated bias due to misclassification of exposure in case control studies. Using a metaanalysis of data from a number of case control studies, in which a possibly misclassified exposure was validated against a more reliable one, estimates of misclassification indices and bias were obtained. The estimates were used to investigate whether misclassification indices, in particular, sensitivity and specificity and so-called quality indices, are typically nondifferential with respect to cases and controls. It is concluded that quality indices do not show any tendency to be either lower or higher in cases than controls. On the other hand, sensitivity tends to be higher in cases than controls and specificity lower. Estimates of misclassification bias may be either positive or negative and are consistent with random variation; there is little to suggest that bias is present in the studies analyzed. AU - Marshall, Roger PY - 1999/06// UR - http://dx.doi.org/10.1016/S0895-4356(99)00028-1 ER -

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