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Hematopoietic Lineage Commitment: miRNAs Add Specificity to a Widely Expressed Transcription Factor

by: Paloma García, Jon Frampton
Developmental Cell, Vol. 14, No. 6. (10 June 2008), pp. 815-816.


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MicroRNAs are important regulators of normal and malignant hematopoiesis. A paper by Lu et al. in this issue of Developmental Cell demonstrates how one microRNA, miR-150, plays a critical role in commitment of the erythroid-megakaryocyte progenitor by modulating the level of the widely expressed transcription factor MYB (or c-Myb).


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