Nonequilibrium Microtubule Fluctuations in a Model Cytoskeleton

by: Clifford P Brangwynne, Gijsje H Koenderink, Frederick C Mackintosh, David A Weitz

Physical Review Letters, Vol. 100, No. 11. (2008)

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Abstract

Biological activity gives rise to nonequilibrium fluctuations in the cytoplasm of cells; however, there are few methods to directly measure these fluctuations. Using a reconstituted actin cytoskeleton, we show that the bending dynamics of embedded microtubules can be used to probe local stress fluctuations. We add myosin motors that drive the network out of equilibrium, resulting in an increased amplitude and modified time dependence of microtubule bending fluctuations. We show that this behavior results from steplike forces on the order of 10 pN driven by collective motor dynamics.

@article{citeulike:2767406, abstract = {Biological activity gives rise to nonequilibrium fluctuations in the cytoplasm of cells; however, there are few methods to directly measure these fluctuations. Using a reconstituted actin cytoskeleton, we show that the bending dynamics of embedded microtubules can be used to probe local stress fluctuations. We add myosin motors that drive the network out of equilibrium, resulting in an increased amplitude and modified time dependence of microtubule bending fluctuations. We show that this behavior results from steplike forces on the order of 10\ pN driven by collective motor dynamics.}, author = {Brangwynne, Clifford P. and Koenderink, Gijsje H. and Mackintosh, Frederick C. and Weitz, David A. }, citeulike-article-id = {2767406}, doi = {10.1103/PhysRevLett.100.118104}, journal = {Physical Review Letters}, keywords = {2008, biology, weitz}, number = {11}, posted-at = {2008-05-07 22:24:02}, priority = {2}, publisher = {APS}, title = {Nonequilibrium Microtubule Fluctuations in a Model Cytoskeleton}, url = {http://scitation.aip.org/getabs/servlet/GetabsServlet?prog=normal\&id=PRLTAO000100000011118104000001\&idtype=cvips\&gifs=yes}, volume = {100}, year = {2008} }

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TY - JOUR ID - citeulike:2767406 TI - Nonequilibrium Microtubule Fluctuations in a Model Cytoskeleton JF - Physical Review Letters VL - 100 IS - 11 PB - APS N2 - Biological activity gives rise to nonequilibrium fluctuations in the cytoplasm of cells; however, there are few methods to directly measure these fluctuations. Using a reconstituted actin cytoskeleton, we show that the bending dynamics of embedded microtubules can be used to probe local stress fluctuations. We add myosin motors that drive the network out of equilibrium, resulting in an increased amplitude and modified time dependence of microtubule bending fluctuations. We show that this behavior results from steplike forces on the order of 10 pN driven by collective motor dynamics. KW - 2008 KW - biology KW - weitz AU - Brangwynne, Clifford AU - Koenderink, Gijsje AU - Mackintosh, Frederick AU - Weitz, David PY - 2008/// UR - http://scitation.aip.org/getabs/servlet/GetabsServlet?prog=normal&id=PRLTAO000100000011118104000001&idtype=cvips&gifs=yes ER -

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