Comparison of transcription regulatory interactions inferred from high-throughput methods: what do they reveal?

by: S Balaji, Lakshminarayan M Iyer, Madan M Babu, L Aravind

Trends in Genetics, Vol. 24, No. 7. (July 2008), pp. 319-323.

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Abstract

We compared the transcription regulatory interactions inferred from three high-throughput methods. Because these methods use different principles, they have few interactions in common, suggesting they capture distinct facets of the transcription regulatory program. We show that these methods uncover disparate biological phenomena: long-range interactions between telomeres and transcription factors, downstream effects of interference with ribosome biogenesis and a protein-aggregation response. Through a detailed analysis of the latter, we predict components of the system responding to protein-aggregation stress.

@article{citeulike:2972799, abstract = {We compared the transcription regulatory interactions inferred from three high-throughput methods. Because these methods use different principles, they have few interactions in common, suggesting they capture distinct facets of the transcription regulatory program. We show that these methods uncover disparate biological phenomena: long-range interactions between telomeres and transcription factors, downstream effects of interference with ribosome biogenesis and a protein-aggregation response. Through a detailed analysis of the latter, we predict components of the system responding to protein-aggregation stress.}, author = {Balaji, S. and Iyer, Lakshminarayan M. and Babu, Madan M. and Aravind, L. }, citeulike-article-id = {2972799}, doi = {http://dx.doi.org/10.1016/j.tig.2008.04.006}, journal = {Trends in Genetics}, keywords = {network, review, transcription}, month = {July}, number = {7}, pages = {319--323}, posted-at = {2008-07-08 16:17:56}, priority = {2}, title = {Comparison of transcription regulatory interactions inferred from high-throughput methods: what do they reveal?}, url = {http://dx.doi.org/10.1016/j.tig.2008.04.006}, volume = {24}, year = {2008} }

RIS record

TY - JOUR ID - citeulike:2972799 L3 - citeulike-article-id:2972799 TI - Comparison of transcription regulatory interactions inferred from high-throughput methods: what do they reveal? JF - Trends in Genetics VL - 24 IS - 7 SP - 319 EP - 323 N2 - We compared the transcription regulatory interactions inferred from three high-throughput methods. Because these methods use different principles, they have few interactions in common, suggesting they capture distinct facets of the transcription regulatory program. We show that these methods uncover disparate biological phenomena: long-range interactions between telomeres and transcription factors, downstream effects of interference with ribosome biogenesis and a protein-aggregation response. Through a detailed analysis of the latter, we predict components of the system responding to protein-aggregation stress. KW - network KW - review KW - transcription AU - Balaji, S AU - Iyer, Lakshminarayan AU - Babu, Madan AU - Aravind, L PY - 2008/07// UR - http://dx.doi.org/10.1016/j.tig.2008.04.006 ER -

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