Genetic characterization of tick-borne flaviviruses: New insights into evolution, pathogenetic determinants and taxonomy

@article{citeulike:2273277, abstract = {Here, we analyze the complete coding sequences of all recognized tick-borne flavivirus species, including Gadgets Gully, Royal Farm and Karshi virus, seabird-associated flaviviruses, Kadam virus and previously uncharacterized isolates of Kyasanur Forest disease virus and Omsk hemorrhagic fever virus. Significant taxonomic improvements are proposed, e.g. the identification of three major groups (mammalian, seabird and Kadam tick-borne flavivirus groups), the creation of a new species (Karshi virus) and the assignment of Tick-borne encephalitis and Louping ill viruses to a unique species (Tick-borne encephalitis virus) including four viral types (i.e. Western Tick-borne encephalitis virus, Eastern Tick-borne encephalitis virus, Turkish sheep Tick-borne encephalitis virus and Louping ill Tick-borne encephalitis virus). The analyses also suggest a complex relationship between viruses infecting birds and those infecting mammals. Ticks that feed on both categories of vertebrates may constitute the evolutionary bridge between the three distinct identified lineages.}, author = {Grard, Gilda and Moureau, Gregory and Charrel, Remi N. and Lemasson, Jean-Jacques and Gonzalez, Jean-Paul and Gallian, Pierre and Gritsun, Tamara S. and Holmes, Edward C. and Gould, Ernest A. and de Lamballerie, Xavier }, citeulike-article-id = {2273277}, doi = {http://dx.doi.org/10.1016/j.virol.2006.09.015}, journal = {Virology}, keywords = {evolution, flavivirus, genetic\_variability, molecular\_analysis, tick\_borne\_viruses}, month = {April}, number = {1}, pages = {80--92}, posted-at = {2008-01-22 11:34:02}, priority = {2}, title = {Genetic characterization of tick-borne flaviviruses: New insights into evolution, pathogenetic determinants and taxonomy}, url = {http://dx.doi.org/10.1016/j.virol.2006.09.015}, volume = {361}, year = {2007} }

TY - JOUR ID - citeulike:2273277 L3 - citeulike-article-id:2273277 TI - Genetic characterization of tick-borne flaviviruses: New insights into evolution, pathogenetic determinants and taxonomy JF - Virology VL - 361 IS - 1 SP - 80 EP - 92 N2 - Here, we analyze the complete coding sequences of all recognized tick-borne flavivirus species, including Gadgets Gully, Royal Farm and Karshi virus, seabird-associated flaviviruses, Kadam virus and previously uncharacterized isolates of Kyasanur Forest disease virus and Omsk hemorrhagic fever virus. Significant taxonomic improvements are proposed, e.g. the identification of three major groups (mammalian, seabird and Kadam tick-borne flavivirus groups), the creation of a new species (Karshi virus) and the assignment of Tick-borne encephalitis and Louping ill viruses to a unique species (Tick-borne encephalitis virus) including four viral types (i.e. Western Tick-borne encephalitis virus, Eastern Tick-borne encephalitis virus, Turkish sheep Tick-borne encephalitis virus and Louping ill Tick-borne encephalitis virus). The analyses also suggest a complex relationship between viruses infecting birds and those infecting mammals. Ticks that feed on both categories of vertebrates may constitute the evolutionary bridge between the three distinct identified lineages. KW - evolution KW - flavivirus KW - genetic_variability KW - molecular_analysis KW - tick_borne_viruses AU - Grard, Gilda AU - Moureau, Gregory AU - Charrel, Remi AU - Lemasson, Jean-Jacques AU - Gonzalez, Jean-Paul AU - Gallian, Pierre AU - Gritsun, Tamara AU - Holmes, Edward AU - Gould, Ernest AU - de Lamballerie, Xavier PY - 2007/04/25/ UR - http://dx.doi.org/10.1016/j.virol.2006.09.015 ER -