Neuronal Transcriptome of Aplysia: Neuronal Compartments and Circuitry

@article{citeulike:1023152, abstract = {SummaryMolecular analyses of Aplysia, a well-established model organism for cellular and systems neural science, have been seriously handicapped by a lack of adequate genomic information. By sequencing cDNA libraries from the central nervous system (CNS), we have identified over 175,000 expressed sequence tags (ESTs), of which 19,814 are unique neuronal gene products and represent 50\%-70\% of the total Aplysia neuronal transcriptome. We have characterized the transcriptome at three levels: (1) the central nervous system, (2) the elementary components of a simple behavior: the gill-withdrawal reflex--by analyzing sensory, motor, and serotonergic modulatory neurons, and (3) processes of individual neurons. In addition to increasing the amount of available gene sequences of Aplysia by two orders of magnitude, this collection represents the largest database available for any member of the Lophotrochozoa and therefore provides additional insights into evolutionary strategies used by this highly successful diversified lineage, one of the three proposed superclades of bilateral animals.}, author = {Moroz, Leonid L. and Edwards, John R. and Puthanveettil, Sathyanarayanan V. and Kohn, Andrea B. and Ha, Thomas and Heyland, Andreas and Knudsen, Bjarne and Sahni, Anuj and Yu, Fahong and Liu, Li }, citeulike-article-id = {1023152}, doi = {10.1016/j.cell.2006.09.052}, journal = {Cell}, keywords = {aplysia, classical, conditioning, instrumental, invertebrate, neurobiology, neuroscience, operant, pavlovian}, month = {December}, number = {7}, pages = {1453--1467}, posted-at = {2007-01-03 10:19:33}, priority = {3}, title = {Neuronal Transcriptome of Aplysia: Neuronal Compartments and Circuitry}, url = {http://dx.doi.org/10.1016/j.cell.2006.09.052}, volume = {127}, year = {2006} }

TY - JOUR ID - citeulike:1023152 L3 - citeulike-article-id:1023152 TI - Neuronal Transcriptome of Aplysia: Neuronal Compartments and Circuitry JF - Cell VL - 127 IS - 7 SP - 1453 EP - 1467 N2 - SummaryMolecular analyses of Aplysia, a well-established model organism for cellular and systems neural science, have been seriously handicapped by a lack of adequate genomic information. By sequencing cDNA libraries from the central nervous system (CNS), we have identified over 175,000 expressed sequence tags (ESTs), of which 19,814 are unique neuronal gene products and represent 50%-70% of the total Aplysia neuronal transcriptome. We have characterized the transcriptome at three levels: (1) the central nervous system, (2) the elementary components of a simple behavior: the gill-withdrawal reflex--by analyzing sensory, motor, and serotonergic modulatory neurons, and (3) processes of individual neurons. In addition to increasing the amount of available gene sequences of Aplysia by two orders of magnitude, this collection represents the largest database available for any member of the Lophotrochozoa and therefore provides additional insights into evolutionary strategies used by this highly successful diversified lineage, one of the three proposed superclades of bilateral animals. KW - aplysia KW - classical KW - conditioning KW - instrumental KW - invertebrate KW - neurobiology KW - neuroscience KW - operant KW - pavlovian AU - Moroz, Leonid AU - Edwards, John AU - Puthanveettil, Sathyanarayanan AU - Kohn, Andrea AU - Ha, Thomas AU - Heyland, Andreas AU - Knudsen, Bjarne AU - Sahni, Anuj AU - Yu, Fahong AU - Liu, Li PY - 2006/12/29/ UR - http://dx.doi.org/10.1016/j.cell.2006.09.052 ER -