Clinical features and pathogenesis of severe malaria

@article{citeulike:2968146, abstract = {A major change in recent years has been the recognition that severe malaria, predominantly caused by Plasmodium falciparum, is a complex multi-system disorder presenting with a range of clinical features. It is becoming apparent that syndromes such as cerebral malaria, which were previously considered relatively clear cut, are not homogenous conditions with a single pathological correlate or pathogenic process. This creates challenges both for elucidating key mechanisms of disease and for identifying suitable targets for adjunctive therapy. The development of severe malaria probably results from a combination of parasite-specific factors, such as adhesion and sequestration in the vasculature and the release of bioactive molecules, together with host inflammatory responses. These include cytokine and chemokine production and cellular infiltrates. This review summarizes progress in several areas presented at a recent meeting.}, author = {Mackintosh, Claire L. and Beeson, James G. and Marsh, Kevin }, citeulike-article-id = {2968146}, doi = {http://dx.doi.org/10.1016/j.pt.2004.09.006}, journal = {Trends in Parasitology}, keywords = {malaria, pathogenesis}, month = {December}, number = {12}, pages = {597--603}, posted-at = {2008-07-07 02:40:02}, priority = {2}, title = {Clinical features and pathogenesis of severe malaria}, url = {http://dx.doi.org/10.1016/j.pt.2004.09.006}, volume = {20}, year = {2004} }

TY - JOUR ID - citeulike:2968146 L3 - citeulike-article-id:2968146 TI - Clinical features and pathogenesis of severe malaria JF - Trends in Parasitology VL - 20 IS - 12 SP - 597 EP - 603 N2 - A major change in recent years has been the recognition that severe malaria, predominantly caused by Plasmodium falciparum, is a complex multi-system disorder presenting with a range of clinical features. It is becoming apparent that syndromes such as cerebral malaria, which were previously considered relatively clear cut, are not homogenous conditions with a single pathological correlate or pathogenic process. This creates challenges both for elucidating key mechanisms of disease and for identifying suitable targets for adjunctive therapy. The development of severe malaria probably results from a combination of parasite-specific factors, such as adhesion and sequestration in the vasculature and the release of bioactive molecules, together with host inflammatory responses. These include cytokine and chemokine production and cellular infiltrates. This review summarizes progress in several areas presented at a recent meeting. KW - malaria KW - pathogenesis AU - Mackintosh, Claire AU - Beeson, James AU - Marsh, Kevin PY - 2004/12// UR - http://dx.doi.org/10.1016/j.pt.2004.09.006 ER -