Early vertebrate whole genome duplications were predated by a period of intense genome rearrangement

@article{citeulike:3000869, abstract = {Researchers, supported by data from polyploid plants, have suggested that whole genome duplication (WGD) may induce genomic instability and rearrangement, an idea which could have important implications for vertebrate evolution. Benefiting from the newly released amphioxus genome sequence (Branchiostoma floridae), an invertebrate which researchers have hoped is representative of the ancestral chordate genome, we have used gene proximity conservation to estimate rates of genome rearrangement throughout vertebrates and some of their invertebrate ancestors. We find that, while amphioxus remains the best single source of invertebrate information about the early chordate genome, its genome structure is not particularly well conserved and it cannot be considered a fossilization of the vertebrate pre-duplication genome. In agreement with previous reports, we identify two WGD events in early vertebrates and another in teleost fish. However, we find that the early vertebrate WGD events were not followed by increased rates of genome rearrangement. Indeed, we measure massive genome rearrangement prior to these WGD events. We propose that the vertebrate WGD events may have been symptoms of a pre-existing predisposition toward genomic structural change. Researchers, supported by data from polyploid plants, have suggested that whole genome duplication (WGD) may induce genomic instability and rearrangement, an idea which could have important implications for vertebrate evolution. Benefiting from the newly released amphioxus genome sequence (Branchiostoma floridae), an invertebrate which researchers have hoped is representative of the ancestral chordate genome, we have used gene proximity conservation to estimate rates of genome rearrangement throughout vertebrates and some of their invertebrate ancestors. We find that, while amphioxus remains the best single source of invertebrate information about the early chordate genome, its genome structure is not particularly well conserved and it cannot be considered a fossilization of the vertebrate pre-duplication genome. In agreement with previous reports, we identify two WGD events in early vertebrates and another in teleost fish. However, we find that the early vertebrate WGD events were not followed by increased rates of genome rearrangement. Indeed, we measure massive genome rearrangement prior to these WGD events. We propose that the vertebrate WGD events may have been symptoms of a pre-existing predisposition toward genomic structural change. 10.1101/gr.080119.108}, author = {Hufton, Andrew L. and Groth, Detlef and Vingron, Martin and Lehrach, Hans and Poustka, Albert J. and Panopoulou, Georgia }, citeulike-article-id = {3000869}, doi = {http://dx.doi.org/10.1101/gr.080119.108}, journal = {Genome Res.}, keywords = {rearrangement, vertebrate}, month = {July}, pages = {gr.080119.108+}, posted-at = {2008-07-17 20:29:47}, priority = {2}, title = {Early vertebrate whole genome duplications were predated by a period of intense genome rearrangement}, url = {http://dx.doi.org/10.1101/gr.080119.108}, year = {2008} }

TY - JOUR ID - citeulike:3000869 L3 - citeulike-article-id:3000869 TI - Early vertebrate whole genome duplications were predated by a period of intense genome rearrangement JF - Genome Res. SP - gr.080119.108 N2 - Researchers, supported by data from polyploid plants, have suggested that whole genome duplication (WGD) may induce genomic instability and rearrangement, an idea which could have important implications for vertebrate evolution. Benefiting from the newly released amphioxus genome sequence (Branchiostoma floridae), an invertebrate which researchers have hoped is representative of the ancestral chordate genome, we have used gene proximity conservation to estimate rates of genome rearrangement throughout vertebrates and some of their invertebrate ancestors. We find that, while amphioxus remains the best single source of invertebrate information about the early chordate genome, its genome structure is not particularly well conserved and it cannot be considered a fossilization of the vertebrate pre-duplication genome. In agreement with previous reports, we identify two WGD events in early vertebrates and another in teleost fish. However, we find that the early vertebrate WGD events were not followed by increased rates of genome rearrangement. Indeed, we measure massive genome rearrangement prior to these WGD events. We propose that the vertebrate WGD events may have been symptoms of a pre-existing predisposition toward genomic structural change. Researchers, supported by data from polyploid plants, have suggested that whole genome duplication (WGD) may induce genomic instability and rearrangement, an idea which could have important implications for vertebrate evolution. Benefiting from the newly released amphioxus genome sequence (Branchiostoma floridae), an invertebrate which researchers have hoped is representative of the ancestral chordate genome, we have used gene proximity conservation to estimate rates of genome rearrangement throughout vertebrates and some of their invertebrate ancestors. We find that, while amphioxus remains the best single source of invertebrate information about the early chordate genome, its genome structure is not particularly well conserved and it cannot be considered a fossilization of the vertebrate pre-duplication genome. In agreement with previous reports, we identify two WGD events in early vertebrates and another in teleost fish. However, we find that the early vertebrate WGD events were not followed by increased rates of genome rearrangement. Indeed, we measure massive genome rearrangement prior to these WGD events. We propose that the vertebrate WGD events may have been symptoms of a pre-existing predisposition toward genomic structural change. 10.1101/gr.080119.108 KW - rearrangement KW - vertebrate AU - Hufton, Andrew AU - Groth, Detlef AU - Vingron, Martin AU - Lehrach, Hans AU - Poustka, Albert AU - Panopoulou, Georgia PY - 2008/07/14/ UR - http://dx.doi.org/10.1101/gr.080119.108 ER -